Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 8/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944912 | 0.86 | TSHR (0.39) | MMP2ALDH1A1HPGDMMP3TSHR | |
| SCHEMBL8021445 | 0.82 | XDH (0.44) | MMP2ALDH1A1HPGDMMP3HRH3 | |
| SCHEMBL7935451 | 0.78 | PPARD (0.43) | KDM4E | |
| SCHEMBL7943031 | 0.77 | ERN1 (0.49) | MMP2ALDH1A1HPGDMMP3TSHR | |
| SCHEMBL14468631 | 0.76 | TRPV4 (0.54) | — | |
| SCHEMBL15372368 | 0.75 | ALDH1A1 (0.38) | ALDH1A1MMP3AR | |
| SCHEMBL12736275 | 0.75 | MMP2 (0.60) | MMP2ALDH1A1HPGDMMP3KDM4E | |
| SCHEMBL2462665 | 0.75 | MMP2 (0.60) | MMP2ALDH1A1HPGDMMP3KDM4E | |
| SCHEMBL6098475 | 0.75 | ERN1 (0.50) | MMP2ALDH1A1HPGDMMP3TSHR | |
| SCHEMBL3997043 | 0.74 | MMP3 (0.46) | ALDH1A1MMP3TSHRHSD17B10AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |