Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979068 | 0.85 | PDE2A (0.40) | ALDH1A1PYGLL3MBTL1PDE2APDE3B | |
| SCHEMBL7938770 | 0.85 | L3MBTL1 (0.38) | ALDH1A1L3MBTL1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL7944573 | 0.84 | TDP1 (0.37) | ALDH1A1L3MBTL1TP53MAPTSLC6A2 | |
| SCHEMBL7946271 | 0.78 | ATM (0.43) | ALDH1A1NPC1KCNH2 | |
| SCHEMBL7938073 | 0.75 | HRH3 (0.37) | ALDH1A1TP53KDM4EMAPTTDP1 | |
| SCHEMBL7969135 | 0.73 | BCHE (0.38) | NPC1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL7947322 | 0.73 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1TP53KDM4EMAPT | |
| SCHEMBL550205 | 0.72 | KCNH2 (0.47) | ALDH1A1L3MBTL1KDM4EMAPTKCNH2 | |
| SCHEMBL8564051 | 0.72 | KCNH2 (0.47) | ALDH1A1L3MBTL1KDM4EMAPTKCNH2 | |
| SCHEMBL7969219 | 0.71 | KMT2A (0.34) | L3MBTL1TP53ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |