Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969135 | 0.81 | BCHE (0.38) | KCNH2NPC1RAB9A | |
| SCHEMBL7951889 | 0.81 | KMT2A (0.41) | HPGDTSHRNPC1ALDH1A1RAB9A | |
| SCHEMBL7938770 | 0.81 | L3MBTL1 (0.38) | KCNH2ALDH1A1 | |
| SCHEMBL7944575 | 0.78 | ALDH1A1 (0.40) | KCNH2NPC1ALDH1A1 | |
| SCHEMBL7938183 | 0.75 | ALDH1A1 (0.37) | KCNH2ALDH1A1 | |
| SCHEMBL7938073 | 0.75 | HRH3 (0.37) | TSHRCYP1A2CYP3A4ALDH1A1HTT | |
| SCHEMBL13896768 | 0.74 | TACR1 (0.44) | HPGDNPC1RAB9AKMT2A | |
| SCHEMBL7986076 | 0.74 | HDAC1 (0.36) | KCNH2ALDH1A1KMT2A | |
| SCHEMBL3749125 | 0.73 | HTR6 (0.53) | POLBKMT2A | |
| SCHEMBL13264880 | 0.73 | ALDH1A1 (0.46) | KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |