Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980884 | 0.86 | BRD4 (0.31) | BRD4 | |
| SCHEMBL6527027 | 0.74 | KCNH2 (0.34) | BRD4SIGMAR1 | |
| SCHEMBL7948151 | 0.72 | LMNA (0.36) | ENPP2DRD2HRH1LMNABRD4 | |
| SCHEMBL7821251 | 0.68 | ENPP2 (0.35) | PTGS2ENPP2LMNABRD4 | |
| SCHEMBL6974957 | 0.67 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL6527029 | 0.66 | BRD4 (0.33) | BRD4SIGMAR1 | |
| SCHEMBL6502022 | 0.63 | MEN1 (0.41) | LMNAMAPT | |
| SCHEMBL31016286 | 0.62 | NPBWR1 (0.38) | PTGS2LMNABRD4 | |
| SCHEMBL28347309 | 0.60 | LRRK2 (0.41) | DRD2LMNADRD3ALDH1A1 | |
| SCHEMBL6637633 | 0.59 | POLB (0.54) | PTGS2ENPP2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |