Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948146 | 0.72 | PTGS2 (0.32) | LMNAENPP2BRD4DRD2HRH1 | |
| SCHEMBL6527031 | 0.72 | ALDH1A1 (0.38) | LMNABRD4AKR1C3AKR1C2SLC6A9 | |
| SCHEMBL7821251 | 0.68 | ENPP2 (0.35) | LMNAENPP2BRD4 | |
| SCHEMBL6980884 | 0.64 | BRD4 (0.31) | BRD4 | |
| SCHEMBL14089194 | 0.64 | NOTUM (0.63) | LMNAALDH1A1 | |
| SCHEMBL21172742 | 0.62 | BRD4 (0.40) | LMNABRD4ALDH1A1 | |
| SCHEMBL28498255 | 0.61 | NOX1 (0.67) | LMNADRD2HRH1DRD3MAPT | |
| SCHEMBL18217887 | 0.60 | LMNA (0.55) | LMNAENPP2AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL21729633 | 0.60 | NOTUM (0.55) | SLC6A9 | |
| SCHEMBL4035842 | 0.58 | PNMT (0.49) | LMNABRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |