Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.73 |
| ▸ | PTPRC | P08575 | 1/20 | 0.73 |
| ▸ | PTPRF | P10586 | 1/20 | 0.73 |
| ▸ | CDC25B | P30305 | 1/20 | 0.73 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.62 |
| ▸ | PRKCB | P05771 | 2/20 | 0.62 |
| ▸ | PRKCA | P17252 | 2/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
| ▸ | PRKACA | P17612 | 1/20 | 0.62 |
| ▸ | PRKACG | P22612 | 1/20 | 0.62 |
| ▸ | PRKACB | P22694 | 1/20 | 0.62 |
| ▸ | CCND1 | P24385 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27795880 | 0.90 | PTPN1 (0.61) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL27771326 | 0.90 | PTPN1 (0.61) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL1158441 | 0.86 | PTPRC (0.60) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL8992461 | 0.84 | PTPN1 (1.00) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL9572016 | 0.84 | PTPN1 (0.77) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL27898411 | 0.82 | PTPN1 (0.64) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL5879323 | 0.80 | PTPRC (0.58) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL2193383 | 0.79 | PRKCB (0.65) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL29771997 | 0.79 | PRKCB (0.65) | PTPN1PTPRCPTPRFCDC25BSIRT2 | |
| SCHEMBL1202543 | 0.79 | IMPDH2 (0.63) | PTPN1PTPRCPTPRFCDC25BSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090838-A | USING 2,5-BISINDOL-3-YL-1,4-QUINONE | SUGEN, INC. (US) | 2000-07-18 | — | — | US | claimed |
| US-6239161-B1 | 2,5-DIHYDROXY-3,6-DI-(INDOL-3-YL)-QUINONE DERIVATIVES; ANTICARCINOGENIC AND ANTIPROLIFERATIVE AGENTS | SUGEN, INC. | 2001-05-29 | — | — | US | disclosed |