Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953114 | 0.85 | ADRB3 (0.35) | ADRB3KMT2A | |
| SCHEMBL7953119 | 0.76 | HTR7 (0.40) | HTR7 | |
| SCHEMBL11603165 | 0.68 | DRD4 (0.72) | MAPTALDH1A1MAPK1DRD4HTR1A | |
| SCHEMBL7953789 | 0.67 | USP2 (0.56) | MAPTMAPK1DRD4HTR1AHTR7 | |
| SCHEMBL7965929 | 0.67 | HTR1A (0.62) | HTR1A | |
| Hydrochloric Acid SCHEMBL11602209 | 0.67 | DRD4 (0.71) | MAPTALDH1A1MAPK1HTTDRD4 | |
| Hydrochloric Acid SCHEMBL9750973 | 0.67 | L3MBTL1 (0.74) | DRD4DRD2CHRNA7MEN1KMT2A | |
| SCHEMBL11881484 | 0.65 | MAPK1 (0.74) | MAPTALDH1A1MAPK1HTTSMN1; SMN2 | |
| SCHEMBL30987490 | 0.64 | CYP11B2 (0.47) | SMN1; SMN2HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL29686987 | 0.63 | L3MBTL1 (0.67) | DRD4DRD2CHRNA7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |