Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 9/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953258 | 0.84 | SLC18A3 (0.40) | KCNH2SLC18A3 | |
| SCHEMBL7953252 | 0.82 | CCR2 (0.35) | GRM2CCR2KCNH2PDCD1LG2CD274 | |
| SCHEMBL7965932 | 0.74 | HTR1A (0.42) | — | |
| SCHEMBL13842724 | 0.66 | CYP11B2 (0.57) | DRD2 | |
| SCHEMBL7408335 | 0.61 | DRD2 (0.60) | GRM2CCR2DRD2 | |
| SCHEMBL27656131 | 0.61 | CYP11B2 (0.53) | — | |
| SCHEMBL15528857 | 0.61 | ACACB (0.44) | GRM2DRD2SLC18A3 | |
| SCHEMBL23374726 | 0.60 | CYP11B2 (0.53) | — | |
| SCHEMBL4397664 | 0.60 | CYP11B2 (0.62) | — | |
| SCHEMBL29351735 | 0.60 | CYP11B2 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |