SCHEMBL7956033

SCHEMBL7956033

CCOC(=O)COc1cccc2cc(COCC(OC)(c3ccccc3)c3ccccc3)oc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 1/20 0.43
ADORA3 P0DMS8 3/20 0.40
ADORA2A P29274 2/20 0.40
ADORA1 P30542 2/20 0.40
CASP3 P42574 1/20 0.39
CASP7 P55210 1/20 0.39
CASP9 P55211 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
GAA P10253 1/20 0.38
ABCB1 P08183 1/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2C19 P33261 2/20 0.37
HPGD P15428 2/20 0.37
POLB P06746 2/20 0.37
CYP2C9 P11712 1/20 0.37
USP2 O75604 1/20 0.37
PTPN1 P18031 1/20 0.37
MEN1 O00255 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7958324 0.89 ADORA3 (0.43) ADORA3ADORA2AADORA1KDM4EALDH1A1
SCHEMBL7956031 0.78 F2RL3 (0.43) F2RL3ADORA3ADORA2AADORA1CASP3
SCHEMBL10933439 0.72 F2RL3 (0.56) F2RL3ADORA3ADORA2AADORA1KDM4E
SCHEMBL10652147 0.71 LMNA (0.61) F2RL3ADORA3ADORA2AADORA1KDM4E
SCHEMBL10649757 0.70 F2RL3 (0.54) F2RL3ADORA3ADORA2AADORA1KDM4E
SCHEMBL10506009 0.69 CA12 (0.52) F2RL3ADORA3ADORA2AADORA1KDM4E
SCHEMBL7958971 0.69 ALDH1A1 (0.49) ADORA3ADORA2AADORA1KDM4EALDH1A1
SCHEMBL7948818 0.68 KDM4E (0.45) ADORA3ADORA2AADORA1KDM4EALDH1A1
SCHEMBL11292775 0.67 AGXT (0.50) CASP3CASP7KDM4EALDH1A1CYP3A4
SCHEMBL7956256 0.66 PTGIR (0.45) ADORA3ADORA2AADORA1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323235-B1 CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS OHTAKE ATSUSHI (JP) 2001-11-27 US disclosed
US-6043264-A A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA TORAY INDUSTRIES, INC. (JP) 2000-03-28 US disclosed
EP-0751126-A1 BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME TORAY INDUSTRIES, INC. (JP) 1997-01-02 EP disclosed