Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963612 | 0.90 | DRD4 (0.38) | MCHR1DRD2DRD3 | |
| SCHEMBL7964115 | 0.85 | MCHR1 (0.38) | MCHR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7960253 | 0.85 | DRD2 (0.43) | MCHR1DRD2HRH3DRD3 | |
| SCHEMBL7963820 | 0.84 | DRD2 (0.47) | MCHR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7963834 | 0.83 | DRD2 (0.48) | MCHR1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7960891 | 0.83 | MCHR1 (0.36) | MCHR1HTR1ADRD2HTR2AHRH3 | |
| SCHEMBL7964142 | 0.83 | DRD2 (0.43) | OPRL1ADRA1DHTR1ADRD2HTR2A | |
| SCHEMBL7959597 | 0.82 | HTR1A (0.41) | OPRL1ADRA1DHTR1ADRD3KCNH2 | |
| SCHEMBL7959473 | 0.81 | MAPT (0.35) | ADRA1DHTR1ADRD2HTR2AHTR6 | |
| SCHEMBL8571313 | 0.79 | DRD2 (0.50) | ADRA1DDRD2HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |