Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 10/20 | 0.38 |
| ▸ | HTR2A | P28223 | 8/20 | 0.38 |
| ▸ | HTR7 | P34969 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960891 | 0.93 | MCHR1 (0.36) | MCHR1DRD2HTR2AHTR6HTR1A | |
| SCHEMBL7963820 | 0.88 | DRD2 (0.47) | MCHR1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL7963834 | 0.87 | DRD2 (0.48) | MCHR1DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL7960253 | 0.87 | DRD2 (0.43) | MCHR1DRD2DRD3PARP1PARP2 | |
| SCHEMBL7949118 | 0.86 | MAPK1 (0.35) | MCHR1DRD2HTR2AHTR7HTR1A | |
| SCHEMBL7959539 | 0.85 | OPRL1 (0.37) | MCHR1DRD2HTR2AHTR6HTR1A | |
| SCHEMBL7957446 | 0.83 | DRD2 (0.50) | DRD2 | |
| SCHEMBL7963786 | 0.82 | SIGMAR1 (0.40) | MCHR1 | |
| SCHEMBL7961291 | 0.82 | SIGMAR1 (0.40) | MCHR1DRD2DRD3PARP1PARP2 | |
| SCHEMBL7959597 | 0.81 | HTR1A (0.41) | HTR1ADRD3PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |