Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963834 | 0.99 | DRD2 (0.48) | DRD2MCHR1DRD3HTR1AHTR2A | |
| SCHEMBL7963786 | 0.89 | SIGMAR1 (0.40) | MCHR1MEN1KMT2ASIGMAR1 | |
| SCHEMBL7961291 | 0.89 | SIGMAR1 (0.40) | DRD2MCHR1DRD3PARP1DRD4 | |
| SCHEMBL7964115 | 0.88 | MCHR1 (0.38) | DRD2MCHR1DRD3HTR1AHTR2A | |
| SCHEMBL7960253 | 0.88 | DRD2 (0.43) | DRD2MCHR1DRD3PARP1DRD4 | |
| SCHEMBL7959434 | 0.87 | DRD2 (0.50) | DRD2DRD3DRD4SIGMAR1 | |
| SCHEMBL7960891 | 0.86 | MCHR1 (0.36) | DRD2MCHR1DRD3HTR1AHTR2A | |
| SCHEMBL7963612 | 0.85 | DRD4 (0.38) | DRD2MCHR1DRD3DRD4MEN1 | |
| SCHEMBL7959539 | 0.84 | OPRL1 (0.37) | DRD2MCHR1DRD3HTR1AHTR2A | |
| SCHEMBL7949118 | 0.84 | MAPK1 (0.35) | DRD2MCHR1HTR1AHTR2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | claimed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |