SCHEMBL7960891

SCHEMBL7960891

Fc1cc(C2CCN(CCCc3onc4c3CCCCC4)CC2)ccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 2/20 0.36
HRH3 Q9Y5N1 4/20 0.36
SLC6A4 P31645 1/20 0.36
PARP1 P09874 2/20 0.36
PARP2 Q9UGN5 2/20 0.36
DRD2 P14416 7/20 0.35
HTR1A P08908 6/20 0.35
HTR2A P28223 6/20 0.35
DRD3 P35462 4/20 0.35
DRD1 P21728 1/20 0.35
DRD5 P21918 1/20 0.35
HTR2C P28335 1/20 0.35
ADRA1A P35348 1/20 0.35
HRH1 P35367 1/20 0.35
HTR6 P50406 1/20 0.35
KCNH2 Q12809 1/20 0.35
ACHE P22303 1/20 0.34
SIGMAR1 Q99720 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7964115 0.93 MCHR1 (0.38) MCHR1PARP1PARP2DRD2HTR1A
SCHEMBL7949118 0.88 MAPK1 (0.35) MCHR1PARP1PARP2DRD2HTR1A
SCHEMBL7963820 0.86 DRD2 (0.47) MCHR1PARP1DRD2HTR1AHTR2A
SCHEMBL7963834 0.85 DRD2 (0.48) MCHR1PARP1DRD2HTR1AHTR2A
SCHEMBL7960253 0.85 DRD2 (0.43) MCHR1HRH3PARP1PARP2DRD2
SCHEMBL7959539 0.83 OPRL1 (0.37) MCHR1HRH3DRD2HTR1AHTR2A
SCHEMBL7957446 0.83 DRD2 (0.50) HRH3SLC6A4DRD2SIGMAR1
SCHEMBL7963786 0.82 SIGMAR1 (0.40) MCHR1HRH3KCNH2SIGMAR1
SCHEMBL7961291 0.82 SIGMAR1 (0.40) MCHR1PARP1PARP2DRD2DRD3
SCHEMBL7959473 0.81 MAPT (0.35) DRD2HTR1AHTR2AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187774-B1 N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-02-13 US disclosed
EP-0885883-A1 FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-12-23 EP disclosed