Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963820 | 0.88 | DRD2 (0.47) | DRD2DRD4DRD3GRM2MCHR1 | |
| SCHEMBL7963834 | 0.87 | DRD2 (0.48) | DRD2DRD4DRD3GRM2MCHR1 | |
| SCHEMBL7964115 | 0.87 | MCHR1 (0.38) | DRD2DRD3MCHR1PARP1PARP2 | |
| SCHEMBL7963612 | 0.85 | DRD4 (0.38) | DRD2DRD4DRD3ALDH1A1MCHR1 | |
| SCHEMBL7960891 | 0.85 | MCHR1 (0.36) | DRD2DRD3MCHR1SIGMAR1PARP1 | |
| SCHEMBL7959539 | 0.85 | OPRL1 (0.37) | DRD2DRD3MCHR1HRH3 | |
| SCHEMBL7957446 | 0.84 | DRD2 (0.50) | DRD2SIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL7964142 | 0.82 | DRD2 (0.43) | DRD2PARP1PARP2 | |
| SCHEMBL7949118 | 0.82 | MAPK1 (0.35) | DRD2DRD4MCHR1SIGMAR1PARP1 | |
| SCHEMBL7959597 | 0.82 | HTR1A (0.41) | DRD4DRD3SIGMAR1PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |