Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959597 | 0.92 | HTR1A (0.41) | HTR1APARP1PARP2ADRA1DOPRL1 | |
| SCHEMBL8571313 | 0.84 | DRD2 (0.50) | DRD2ADRA1D | |
| SCHEMBL7963612 | 0.83 | DRD4 (0.38) | DRD2 | |
| SCHEMBL7959539 | 0.83 | OPRL1 (0.37) | DRD2HTR1AHTR2AHTR2CADRA1D | |
| SCHEMBL7960253 | 0.82 | DRD2 (0.43) | DRD2PARP1PARP2 | |
| SCHEMBL7963820 | 0.82 | DRD2 (0.47) | DRD2HTR1AHTR2APARP1 | |
| SCHEMBL7963834 | 0.81 | DRD2 (0.48) | DRD2HTR1AHTR2APARP1 | |
| SCHEMBL7959473 | 0.81 | MAPT (0.35) | DRD2HTR1AHTR2AADRA1DADRA1B | |
| SCHEMBL7960891 | 0.79 | MCHR1 (0.36) | DRD2HTR1AHTR2AHTR2CPARP1 | |
| SCHEMBL7964115 | 0.79 | MCHR1 (0.38) | DRD2HTR1AHTR2APARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |