Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.45 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960165 | 0.89 | PKM (0.52) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7957371 | 0.85 | LMNA (0.52) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7959708 | 0.84 | DRD2 (0.55) | HSD11B1HSD11B2DRD2HTR1AHTR2A | |
| SCHEMBL7959210 | 0.83 | DRD2 (0.45) | LMNASHMT2GAADRD2HPGD | |
| SCHEMBL7959714 | 0.83 | GAA (0.50) | LMNASHMT2HSD11B1GAADRD2 | |
| SCHEMBL7957105 | 0.83 | DRD2 (0.46) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7959533 | 0.81 | DRD2 (0.48) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7963703 | 0.81 | HSD11B1 (0.41) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7963490 | 0.79 | LMNA (0.46) | LMNASHMT2HSD11B1HSD11B2GAA | |
| SCHEMBL7957541 | 0.78 | OPRM1 (0.58) | DRD2HTR1AHTR2ADRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |