SCHEMBL7963786

SCHEMBL7963786

Brc1ccc(C2CCN(CCCc3onc4c3CCCCC4)CC2)cc1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.40
CYP3A4 P08684 2/20 0.37
MEN1 O00255 1/20 0.37
TP53 P04637 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
TSHR P16473 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
MCHR1 Q99705 1/20 0.36
HRH3 Q9Y5N1 4/20 0.36
KCNH2 Q12809 3/20 0.36
CYP2C9 P11712 1/20 0.35
SLC18A3 Q16572 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7963820 0.89 DRD2 (0.47) SIGMAR1MEN1KMT2AMCHR1
SCHEMBL7961291 0.89 SIGMAR1 (0.40) SIGMAR1CYP3A4MEN1TP53CYP1A2
SCHEMBL7963834 0.88 DRD2 (0.48) SIGMAR1MEN1KMT2AMCHR1
SCHEMBL7959434 0.87 DRD2 (0.50) SIGMAR1CYP3A4TP53HRH3KCNH2
SCHEMBL7957446 0.84 DRD2 (0.50) SIGMAR1CYP3A4MEN1TP53CYP1A2
SCHEMBL7964115 0.82 MCHR1 (0.38) MCHR1
SCHEMBL7960891 0.82 MCHR1 (0.36) SIGMAR1MCHR1HRH3KCNH2
SCHEMBL7960253 0.82 DRD2 (0.43) SIGMAR1CYP3A4MEN1TP53CYP1A2
SCHEMBL7949118 0.80 MAPK1 (0.35) SIGMAR1MCHR1
SCHEMBL7959597 0.79 HTR1A (0.41) SIGMAR1CYP3A4MEN1CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187774-B1 N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-02-13 US disclosed
EP-0885883-A1 FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-12-23 EP disclosed