Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953304 | 0.85 | OPRL1 (0.38) | ALDH1A1KDM4EHTR1AMAPTL3MBTL1 | |
| SCHEMBL7953297 | 0.85 | LMNA (0.55) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7953292 | 0.84 | MAPT (0.41) | ALDH1A1KDM4EMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7964658 | 0.83 | MEN1 (0.48) | ALDH1A1DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL7965519 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EDRD2HTR1AHTR2A | |
| SCHEMBL7963819 | 0.83 | MAOA (0.46) | DRD2HTR1AHTR2AHTR7MAPT | |
| SCHEMBL7962754 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KDM4EDRD2HTR1AHTR2A | |
| SCHEMBL7966346 | 0.82 | CYP2D6 (0.49) | ALDH1A1KDM4EHTR2AHTR7MEN1 | |
| Oxalic Acid SCHEMBL7966526 | 0.79 | KDM4E (0.54) | ALDH1A1KDM4EDRD2HTR1AHTR2A | |
| Oxalic Acid SCHEMBL7965012 | 0.79 | KDM4E (0.46) | ALDH1A1KDM4EDRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |