Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963819 | 0.95 | MAOA (0.46) | NPC1RAB9AOPRM1OPRD1DRD2 | |
| SCHEMBL7965014 | 0.86 | OPRM1 (0.43) | KDM4ENPC1RAB9ASMN1; SMN2OPRM1 | |
| Oxalic Acid SCHEMBL7966526 | 0.85 | KDM4E (0.54) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| Oxalic Acid SCHEMBL7966500 | 0.81 | KMT2A (0.52) | KDM4EALDH1A1DRD2DRD3HTR7 | |
| SCHEMBL7964394 | 0.81 | OPRL1 (0.43) | OPRM1OPRD1DRD2CCR1DRD3 | |
| SCHEMBL7964392 | 0.81 | CYP1A2 (0.58) | SMN1; SMN2 | |
| SCHEMBL7962754 | 0.81 | ALDH1A1 (0.56) | KDM4ESMN1; SMN2ALDH1A1DRD2CCR1 | |
| SCHEMBL7964386 | 0.80 | LMNA (0.39) | KDM4ENPC1RAB9ASMN1; SMN2OPRM1 | |
| SCHEMBL7964899 | 0.79 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2ALDH1A1DRD2DRD3 | |
| SCHEMBL7965519 | 0.77 | ALDH1A1 (0.51) | KDM4EALDH1A1DRD2CCR1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |