Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966346 | 0.83 | CYP2D6 (0.49) | ALDH1A1CYP1A2CYP2D6MEN1KMT2A | |
| SCHEMBL7964899 | 0.83 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL7962754 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ALMNAIGF1R | |
| SCHEMBL7963819 | 0.81 | MAOA (0.46) | MAPTLMNACCR1TP53DRD2 | |
| SCHEMBL7970239 | 0.80 | GAA (0.43) | MEN1KMT2AMAPTGAALMNA | |
| Oxalic Acid SCHEMBL7966500 | 0.80 | KMT2A (0.52) | ALDH1A1CYP1A2CYP2D6MEN1KMT2A | |
| SCHEMBL7967101 | 0.80 | HTR1A (0.40) | HTR1AHTR7HTR2ASLC6A4DRD3 | |
| SCHEMBL7964658 | 0.80 | MEN1 (0.48) | ALDH1A1MEN1KMT2ALMNAIGF1R | |
| Oxalic Acid SCHEMBL7966526 | 0.79 | KDM4E (0.54) | ALDH1A1MEN1KMT2ALMNADRD2 | |
| Oxalic Acid SCHEMBL7965012 | 0.77 | KDM4E (0.46) | ALDH1A1CCR1DRD2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |