Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 8/20 | 0.32 |
| ▸ | TACR1 | P25103 | 6/20 | 0.32 |
| ▸ | TACR2 | P21452 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7965940 | 0.85 | HTR1A (0.38) | — | |
| Bromide SCHEMBL7965945 | 0.83 | — | — | |
| SCHEMBL7962999 | 0.81 | OPRL1 (0.40) | OPRM1OPRL1OPRD1 | |
| SCHEMBL7965454 | 0.76 | OPRL1 (0.36) | OPRM1OPRL1TACR2 | |
| SCHEMBL8139378 | 0.75 | SLC6A1 (0.34) | OPRM1OPRL1OPRD1TACR1TACR2 | |
| SCHEMBL7963100 | 0.75 | SLC6A1 (0.34) | OPRM1OPRL1OPRD1TACR1TACR2 | |
| SCHEMBL7965345 | 0.73 | SLC6A1 (0.34) | OPRL1 | |
| SCHEMBL7965744 | 0.73 | HTR1A (0.36) | — | |
| SCHEMBL7967096 | 0.72 | TUBB4A (0.38) | OPRM1OPRL1OPRD1 | |
| SCHEMBL7953976 | 0.71 | SLC6A2 (0.38) | OPRM1OPRL1TACR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |