Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963227 | 0.78 | LMNA (0.36) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL7965432 | 0.75 | MAPT (0.34) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL8536893 | 0.71 | MAPT (0.52) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL8911552 | 0.70 | SMN1; SMN2 (0.36) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL9434368 | 0.68 | SMN1; SMN2 (0.36) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL9434365 | 0.66 | FGB (0.42) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL9434910 | 0.65 | HRH3 (0.37) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL7969917 | 0.65 | — | — | |
| SCHEMBL1388444 | 0.64 | FGB (0.38) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL9434110 | 0.64 | SMN1; SMN2 (0.36) | KDM4EALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201129-B1 | ANTICARCINOGENIC AGENTS | UNIV. COLLEGE CARDIFF CONSULTANTS (GB) | 2001-03-13 | — | — | US | claimed |
| EP-0807113-A1 | TRICYCLIC DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | University College Cardiff Consultants Limited (GB) | 1997-11-19 | — | — | EP | claimed |
| US-6201129-B1 | ANTICARCINOGENIC AGENTS | UNIV. COLLEGE CARDIFF CONSULTANTS (GB) | 2001-03-13 | — | — | US | disclosed |
| EP-0807113-A1 | TRICYCLIC DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | University College Cardiff Consultants Limited (GB) | 1997-11-19 | — | — | EP | disclosed |
| WO-1995021171-A1 | TRICYCLIC DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |