Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910413 | 0.77 | FGB (0.41) | SMN1; SMN2HTTMAPTCYP1A2CYP3A4 | |
| SCHEMBL8536893 | 0.76 | MAPT (0.52) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL8150303 | 0.72 | MAPT (0.41) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL9434365 | 0.72 | FGB (0.42) | SMN1; SMN2NPC1RAB9AHSD17B2HTT | |
| SCHEMBL7966334 | 0.70 | KDM4E (0.36) | SMN1; SMN2RAB9AHTTMAPTNPSR1 | |
| SCHEMBL7963227 | 0.70 | LMNA (0.36) | SMN1; SMN2HTTMAPTCYP1A2CYP2C19 | |
| SCHEMBL9434368 | 0.70 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL9435019 | 0.69 | ALDH1A1 (0.35) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL9434910 | 0.69 | HRH3 (0.37) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL7965432 | 0.68 | MAPT (0.34) | SMN1; SMN2HTTMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |