Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970058 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL9181274 | 0.80 | RAB9A (0.65) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL7970056 | 0.75 | LMNA (0.47) | MEN1KMT2AMAPTTUBB4ATUBB | |
| SCHEMBL7970053 | 0.75 | LMNA (0.47) | MEN1KMT2AMAPTTUBB4ATUBB | |
| SCHEMBL8726720 | 0.72 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL7786089 | 0.72 | RAB9A (0.87) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL3862633 | 0.71 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL283216 | 0.70 | CYP19A1 (0.67) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7980263 | 0.68 | CYP1A1 (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3643547 | 0.68 | NPC1 (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |