Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7989254 | 0.83 | CYP11B1 (0.49) | SMN1; SMN2POLBLMNAMAPTTSHR | |
| SCHEMBL7988530 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAMAPTHTTTP53 | |
| SCHEMBL7974324 | 0.80 | TNF (0.44) | TNFSMN1; SMN2POLBLMNAMAPT | |
| SCHEMBL7975372 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2POLBLMNAMAPTHTT | |
| SCHEMBL7989347 | 0.78 | CYP11B1 (0.44) | LMNAMAPTTSHRALDH1A1KMT2A | |
| SCHEMBL7987589 | 0.76 | ACP1 (0.50) | SMN1; SMN2HTTNPC1RAB9ATSHR | |
| SCHEMBL7984755 | 0.73 | LMNA (0.56) | POLBLMNANPC1RAB9ATSHR | |
| SCHEMBL7984782 | 0.73 | ALDH1A1 (0.43) | LMNAMAPTTP53NPC1RAB9A | |
| SCHEMBL7988189 | 0.72 | ADORA2A (0.42) | LMNATP53TSHRALDH1A1CYP3A4 | |
| SCHEMBL5483136 | 0.72 | PKM (0.59) | TNFLMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |