Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975372 | 0.86 | ALDH1A1 (0.51) | CYP11B1CYP11B2PKMGAATSHR | |
| SCHEMBL7988530 | 0.85 | SMN1; SMN2 (0.46) | CYP11B1CYP11B2PARP10PKMGAA | |
| SCHEMBL7987927 | 0.80 | HSP90AA1 (0.53) | TSHRALDH1A1KMT2A | |
| SCHEMBL5483136 | 0.79 | PKM (0.59) | CYP11B1CYP11B2PKMGAATSHR | |
| SCHEMBL7974058 | 0.78 | TNF (0.50) | TSHRLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL7985495 | 0.78 | CYP11B1 (0.39) | CYP11B1CYP11B2PARP10TSHRLMNA | |
| SCHEMBL7987743 | 0.78 | SCD (0.50) | CYP11B1CYP11B2PKMGAATSHR | |
| Hydrochloric Acid SCHEMBL7987445 | 0.78 | PKM (0.57) | CYP11B1CYP11B2PKMGAATSHR | |
| SCHEMBL7987245 | 0.77 | ROCK2 (0.47) | LMNAALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL7985719 | 0.77 | GAA (0.41) | PARP10PKMGAATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |