Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984751 | 0.89 | NTRK1 (0.46) | TP53LMNARXFP1MAPTMEN1 | |
| SCHEMBL7991521 | 0.89 | ADORA3 (0.47) | TP53RXFP1MAPTAURKAMEN1 | |
| SCHEMBL7987851 | 0.87 | LMNA (0.46) | TP53LMNARXFP1MAPTMEN1 | |
| SCHEMBL7991269 | 0.85 | TP53 (0.46) | TP53LMNARXFP1MAPTMEN1 | |
| SCHEMBL7987938 | 0.84 | KDM4E (0.44) | TP53LMNARXFP1MAPTMEN1 | |
| SCHEMBL7974240 | 0.83 | RAB9A (0.47) | MAPTAURKAMEN1KMT2ATDP1 | |
| SCHEMBL7974172 | 0.83 | HDAC3 (0.44) | LMNAHSD17B13SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7985375 | 0.82 | KDM4E (0.47) | TP53RXFP1MAPTAURKATDP1 | |
| SCHEMBL7988763 | 0.82 | NR1H4 (0.43) | TP53LMNAMAPTTDP1SMN1; SMN2 | |
| SCHEMBL7987763 | 0.81 | RAB9A (0.44) | AURKAMEN1KMT2ATDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |