Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 10/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7973000 | 0.87 | ACE (0.50) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL1543546 | 0.87 | ACE (0.56) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL187408 | 0.87 | ACE (0.56) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL750903 | 0.87 | ACE (0.56) | LMNAHSD17B10CYP2C19ACEREN | |
| Bromide SCHEMBL6544002 | 0.85 | ACE (0.55) | LMNAHSD17B10CYP2C19ACEREN | |
| Ammonia Solution, Strong SCHEMBL29036066 | 0.85 | ACE (0.55) | LMNAHSD17B10CYP2C19ACEREN | |
| Ammonia Solution, Strong SCHEMBL29036064 | 0.85 | ACE (0.55) | LMNAHSD17B10CYP2C19ACEREN | |
| Bicarbonate SCHEMBL7972998 | 0.83 | ACE (0.53) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL7959683 | 0.81 | ACE (0.49) | LMNAHSD17B10CYP2C19ACEREN | |
| SCHEMBL6478173 | 0.81 | ACE (0.50) | ACEREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001029050-A2 | CONDENSED PYRROLE DERIVATIVES AS NEURAMINIDASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |