Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974434 | 0.92 | POLB (0.65) | POLBTDP1APEX1CTDSP1L3MBTL1 | |
| SCHEMBL7964027 | 0.90 | POLB (0.71) | POLBTDP1APEX1CTDSP1L3MBTL1 | |
| SCHEMBL7964168 | 0.89 | POLB (0.70) | POLBTDP1APEX1CTDSP1L3MBTL1 | |
| SCHEMBL7977587 | 0.82 | NPC1 (0.58) | POLBTDP1CTDSP1NPC1RAB9A | |
| SCHEMBL7974288 | 0.82 | KMT2A (0.65) | POLBTDP1CTDSP1NPC1RAB9A | |
| SCHEMBL7977633 | 0.81 | SMN1; SMN2 (0.56) | POLBNPC1RAB9AMPOLMNA | |
| SCHEMBL7974413 | 0.81 | SMN1; SMN2 (0.59) | POLBTDP1NPC1RAB9AMPO | |
| SCHEMBL7977571 | 0.81 | NPC1 (0.53) | POLBNPC1RAB9AMPOLMNA | |
| SCHEMBL7977544 | 0.79 | LMNA (0.57) | NPC1RAB9AMPOCYP1A2CYP2C19 | |
| SCHEMBL7980306 | 0.79 | NPSR1 (0.49) | POLBTDP1NPC1RAB9AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |