Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964029 | 0.84 | RAB9A (0.70) | TSHRRAB9AHSD17B10MAPTALOX15 | |
| SCHEMBL7977544 | 0.82 | LMNA (0.57) | TSHRCYP1A2CYP2D6CYP2C19RAB9A | |
| SCHEMBL7977631 | 0.82 | CYP1A2 (0.52) | TSHRCYP1A2CYP2D6CYP2C19RAB9A | |
| SCHEMBL7980306 | 0.81 | NPSR1 (0.49) | TSHRCYP1A2CYP2D6CYP2C19RAB9A | |
| SCHEMBL7980389 | 0.81 | NPC1 (0.49) | TSHRCYP1A2CYP2D6CYP2C19RAB9A | |
| SCHEMBL7974413 | 0.80 | SMN1; SMN2 (0.59) | CYP1A2CYP2C19RAB9AKDM4EGAA | |
| SCHEMBL7977571 | 0.80 | NPC1 (0.53) | RAB9AMAPK1NPC1MPO | |
| SCHEMBL7975349 | 0.79 | CYP1A2 (0.51) | TSHRCYP1A2CYP2D6CYP2C19RAB9A | |
| SCHEMBL7977463 | 0.79 | HPGD (0.54) | TSHRRAB9ANPSR1KDM4EGAA | |
| SCHEMBL7974434 | 0.79 | POLB (0.65) | CYP1A2CYP2C19RAB9AUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |