Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969979 | 0.91 | MAPT (0.50) | MAPTSMN1; SMN2KMT2AMEN1PIK3R1 | |
| SCHEMBL7032527 | 0.81 | QPCT (0.53) | MAPTSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL30934954 | 0.78 | MEN1 (0.70) | MAPTSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL7225918 | 0.78 | MEN1 (0.70) | MAPTSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL9980488 | 0.78 | PDE1B (0.56) | SMN1; SMN2KMT2AMEN1DCTPP1 | |
| SCHEMBL30807014 | 0.76 | PKM (0.55) | KMT2AMEN1RAB9A | |
| SCHEMBL4042951 | 0.76 | PDE5A (0.54) | MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7979884 | 0.75 | GABRA5 (0.68) | PIK3R1PIK3CA | |
| SCHEMBL9095882 | 0.74 | ALDH1A1 (0.64) | MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2862612 | 0.74 | IDO1 (0.56) | MAPTSMN1; SMN2PIK3R1PIK3CADCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |