Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979757 | 0.91 | MAPT (0.50) | MAPTSMN1; SMN2PIK3R1PIK3CANPC1 | |
| SCHEMBL30807014 | 0.86 | PKM (0.55) | RAB9AKMT2AMEN1CNR2CNR1 | |
| SCHEMBL21608846 | 0.81 | PIK3R1 (0.51) | MAPTSMN1; SMN2PIK3R1PIK3CAKMT2A | |
| SCHEMBL30806660 | 0.81 | CFTR (0.52) | MAPTKMT2A | |
| SCHEMBL21609024 | 0.78 | PDE1B (0.50) | MAPTSMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL7225918 | 0.78 | MEN1 (0.70) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL30934954 | 0.78 | MEN1 (0.70) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL30806751 | 0.77 | ALOX5 (0.44) | MAPTKMT2AMEN1 | |
| SCHEMBL7979884 | 0.75 | GABRA5 (0.68) | PIK3R1PIK3CA | |
| SCHEMBL20401101 | 0.74 | GLS (0.57) | MAPTSMN1; SMN2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |