Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.59 |
| ▸ | MAOB | P27338 | 8/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | VHL | P40337 | 1/20 | 0.49 |
| ▸ | ELOC | Q15369 | 1/20 | 0.49 |
| ▸ | ELOB | Q15370 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29673182 | 0.96 | MAOA (0.59) | MAOAMAOBF7PARP1F3 | |
| SCHEMBL1998628 | 0.96 | MAOA (0.59) | MAOAMAOBF7PARP1F3 | |
| SCHEMBL29506179 | 0.88 | PBRM1 (0.59) | MAOAMAOBF7PARP1F3 | |
| SCHEMBL1151032 | 0.88 | PBRM1 (0.59) | MAOAMAOBF7PARP1F3 | |
| SCHEMBL5108894 | 0.84 | MAOA (0.61) | MAOAMAOBVHLELOCELOB | |
| SCHEMBL1798900 | 0.80 | MAOA (0.67) | MAOAMAOBVHLELOCELOB | |
| SCHEMBL17011806 | 0.79 | MAOA (0.56) | MAOAMAOBVHLELOCELOB | |
| SCHEMBL15369023 | 0.77 | MAOA (0.52) | MAOAMAOBF7PARP1F3 | |
| SCHEMBL16559383 | 0.77 | F7 (0.58) | MAOBF7PARP1F3PARP10 | |
| SCHEMBL27844098 | 0.77 | MAOA (0.49) | MAOAMAOBVHLELOCELOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218381-B1 | SPIRO-THIAZOLONES | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-10092551-B2 | Spiro-thiazolones | HOFFMANN-LAROCHE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-3218381-A1 | SPIRO-THIAZOLONES | F. Hoffmann-La Roche AG (CH) | 2017-09-20 | — | — | EP | disclosed |
| US-20170246153-A1 | SPIRO-THIAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2017-08-31 | — | — | US | disclosed |
| WO-2016075181-A1 | SPIRO-THIAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-19 | — | — | WO | disclosed |
| EP-2053095-B1 | Ink composition and inkjet recording method using the same | FUJIFILM CORP (JP) | 2014-03-26 | — | — | EP | disclosed |
| EP-1741693-B1 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ALCOHOLS | NAGOYA IND SCIENCE RES INST (JP) | 2011-08-03 | — | — | EP | disclosed |
| US-20070225528-A1 | Process for Producing Optically Active Alcohol | NAGOYA INDUSTRIAL SCIENCE RESEARCH CENTER (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1741693-A1 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ALCOHOLS | Nagoya Industrial Science Research Institute (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2001064675-A1 | CONDENSED THIAZOLAMINES AND THEIR USE AS NEUROPEPTIDE Y5 ANTAGONISTS | NOVARTIS AG (CH) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225528-A1 | Process for Producing Optically Active Alcohol | ADH1C, ADH1A, ADH5 | MAOA 2342/4885MAOB 1866/4885F7 1213/4885 |
| US-10092551-B2 | Spiro-thiazolones | AVPR1A, AVPR2, AVPR1B | MAOA 1140/4885MAOB 1797/4885F7 3301/4885 |
| US-20170246153-A1 | SPIRO-THIAZOLONES | AVPR1A, AVPR2, AVPR1B | MAOA 1140/4885MAOB 1797/4885F7 3301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.