Sugi Predict

Sugi Predict / Compounds / SCHEMBL1151032

SCHEMBL1151032

SCHEMBL1151032

O=C1CCc2ccc(Cl)cc21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PBRM1 Q86U86 1/20 0.59
▸ F7 P08709 1/20 0.56
▸ PARP1 P09874 1/20 0.56
▸ F3 P13726 1/20 0.56
▸ PARP10 Q53GL7 1/20 0.56
▸ VHL P40337 1/20 0.52
▸ ELOC Q15369 1/20 0.52
▸ ELOB Q15370 1/20 0.52
▸ S100A4 P26447 1/20 0.46
▸ TYMS P04818 2/20 0.46
▸ MAOA P21397 1/20 0.46
▸ MAOB P27338 1/20 0.46
▸ METAP1 P53582 1/20 0.44
▸ CASP1 P29466 1/20 0.44
▸ CASP7 P55210 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ PTGS1 P23219 1/20 0.43
▸ PTGS2 P35354 1/20 0.43
▸ PPOX P50336 1/20 0.42
▸ SRD5A1 P18405 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29506179 1.00 PBRM1 (0.59) PBRM1F7PARP1F3PARP10
SCHEMBL29673182 0.88 MAOA (0.59) PBRM1F7PARP1F3PARP10
SCHEMBL1998628 0.88 MAOA (0.59) PBRM1F7PARP1F3PARP10
SCHEMBL7983259 0.88 MAOA (0.59) PBRM1F7PARP1F3PARP10
SCHEMBL16559383 0.84 F7 (0.58) F7PARP1F3PARP10VHL
SCHEMBL28603 0.83 CASP1 (0.59) PBRM1VHLELOCELOBS100A4
SCHEMBL31029247 0.83 CASP1 (0.59) PBRM1VHLELOCELOBS100A4
Hydrochloric Acid SCHEMBL28688881 0.79 CASP1 (0.55) F7PARP1F3PARP10VHL
SCHEMBL17080960 0.79 VHL (0.45) PBRM1F7PARP1F3PARP10
SCHEMBL9822238 0.78 NOTUM (0.51) PBRM1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113861113-B Preparation and application of fused ring pyridine compound and derivative thereof 中国科学院福建物质结构研究所 2022-12-06 — — CN claimed
CN-113861113-A Preparation and application of fused ring pyridine compound and derivative thereof 中国科学院福建物质结构研究所 2021-12-31 — — CN claimed
EP-2943460-B1 6-CHLORO-3-(PHENYL-D5)-INDEN-1-ONE AND USE THEREOF H LUNDBECK AS (DK) 2020-02-12 — — EP claimed
US-9309165-B2 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof H. LUNDBECK A/S (DK) 2016-04-12 — — US claimed
US-20150336867-A1 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof H. LUNDBECK A/S (DK) 2015-11-26 — — US claimed
EP-4585265-A2 HETEROARYL INHIBITORS OF PLASMA KALLIKREIN Takeda Pharmaceutical Company Limited (JP) 2025-07-16 — — EP disclosed
US-20250205204-A1 Transcription Factor Brn2 Inhibitory Compounds for Use as Therapeutics THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2025-06-26 — — US disclosed
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2025-02-27 — — US disclosed
CN-119462458-A Covalent inhibitor of targeted hCES A and preparation method and application thereof 中国人民解放军海军军医大学 2025-02-18 — — CN disclosed
US-12187721-B2 Protein tyrosine phosphatase inhibitors ARRAY BIOPHARMA INC. (US) 2025-01-07 — — US disclosed
US-20240398772-A1 OXASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF JIANGSU NHWA PHARMACEUTICAL CO., LTD (CN) 2024-12-05 — — US disclosed
US-20240368001-A1 SALT RECOVERY SOLUTION AND PROCESSES OF USE THEREOF AQUAFORTUS TECHNOLOGIES LIMITED (NZ) 2024-11-07 — — US disclosed
EP-0657426-A2 Tricyclic pyrrole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1995-06-14 — — EP disclosed
WO-1994026692-A1 BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-24 — — WO disclosed
EP-0035363-B1 INDANE DERIVATIVES, METHODS OF THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM KEFALAS A/S (DK) 1985-05-02 — — EP disclosed
US-4443448-A ANALGESICS, ANTIDEPRESSANTS, NEUROLEPTICS KEFALAS A/S (DK) 1984-04-17 — — US disclosed
US-4357337-A PIPERIDINYLALKYL DERIVATIVES PHARMINDUSTRIE (FR) 1982-11-02 — — US disclosed
EP-0035363-A1 Indane derivatives, methods of their preparation and compositions containing them KEFALAS A/S (DK) 1981-09-09 — — EP disclosed
US-4226875-A Novel spiro-oxazolidinediones PFIZER INC. (US) 1980-10-07 — — US disclosed
US-4174397-A TREATMENT OF OBESITY AND LIPID METABOLISM DISORDERS HOECHST AKTIENGESELLSCHAFT (DE) 1979-11-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066357-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS PPM1A, PPM1F, PPP5C PBRM1 616/4885F7 4091/4885PARP1 4138/4885
US-12187721-B2 Protein tyrosine phosphatase inhibitors PPM1A, PTP4A1, PPP5C PBRM1 698/4885F7 3796/4885PARP1 4225/4885
US-20240398772-A1 OXASPIRO DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF OGFR, OPRL1, OPRM1 PBRM1 2258/4885F7 1971/4885PARP1 4777/4885
US-20150336867-A1 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof CYP2D6, UGT1A6, IDO1 PBRM1 3714/4885F7 2690/4885PARP1 404/4885
US-20250205204-A1 Transcription Factor Brn2 Inhibitory Compounds for Use as Therapeutics BRDT, BRPF3, BRIX1 PBRM1 256/4885F7 3330/4885PARP1 1393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.