Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CNOT7 | Q9UIV1 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984465 | 0.93 | CNOT7 (0.41) | MAPK14CNOT7ALDH1A1CASRNR1I2 | |
| SCHEMBL7974646 | 0.88 | MAPK14 (0.47) | MAPK14CNOT7ALDH1A1POLBMAPT | |
| SCHEMBL7974615 | 0.84 | ADORA2A (0.44) | HTTCNOT7ALDH1A1ADORA2APKM | |
| SCHEMBL7973871 | 0.84 | ADORA3 (0.40) | HTTMAPK14CNOT7ALDH1A1ADORA2A | |
| SCHEMBL7985446 | 0.83 | GBA1 (0.41) | HTTMAPK14CNOT7ALDH1A1MAPT | |
| SCHEMBL7985288 | 0.82 | NPC1 (0.41) | HTTCNOT7ALDH1A1 | |
| SCHEMBL7988184 | 0.81 | MET (0.42) | HTTMAPK14ALDH1A1MAPTMAPK1 | |
| SCHEMBL7973917 | 0.81 | LMNA (0.40) | MAPK14ALDH1A1POLBMAPTADORA2A | |
| SCHEMBL7988454 | 0.81 | MAPK14 (0.41) | MAPK14 | |
| SCHEMBL7984683 | 0.81 | CNOT7 (0.37) | HTTCNOT7ALDH1A1CASRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |