Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.51 |
| ▸ | TDP2 | O95551 | 6/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984591 | 0.74 | PTGES (0.61) | PTGESTDP2USP8MAPTMEN1 | |
| SCHEMBL7984632 | 0.72 | USP8 (0.60) | PTGESUSP8MAPTMEN1MAPK1 | |
| SCHEMBL7983849 | 0.72 | PTGES (0.57) | PTGESUSP8MAPTMEN1MAPK1 | |
| SCHEMBL7996719 | 0.71 | PTGES (0.64) | PTGESUSP8MAPTMEN1KMT2A | |
| SCHEMBL23876437 | 0.68 | PTGES (1.00) | PTGESMAPTMEN1MAPK1KMT2A | |
| SCHEMBL7984832 | 0.66 | PTGES (0.63) | PTGESMAPTMEN1MAPK1KMT2A | |
| SCHEMBL830132 | 0.65 | PREP (0.41) | SIRT2RXFP1ALDH1A1GAA | |
| SCHEMBL7984580 | 0.65 | RAB9A (0.60) | PTGESUSP8MAPTMEN1MAPK1 | |
| SCHEMBL29432454 | 0.65 | RAB9A (0.60) | PTGESUSP8MAPTMEN1MAPK1 | |
| SCHEMBL8002271 | 0.64 | ALDH1A1 (0.64) | MEN1KMT2AAPPRXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |