Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.63 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996575 | 0.91 | PTGES (0.55) | PTGESBRD4SGMS2MAPK1MAPT | |
| SCHEMBL7994940 | 0.88 | PTGES (0.52) | PTGESBRD4SGMS2 | |
| SCHEMBL7994971 | 0.85 | PTGES (0.59) | PTGESBRD4KCNA3 | |
| SCHEMBL7984763 | 0.82 | PTGES (0.54) | PTGESMAPK1TDP1L3MBTL1MAPT | |
| SCHEMBL7996440 | 0.82 | PTGES (0.54) | PTGESMAPK1L3MBTL1MAPTMEN1 | |
| Trifluoroacetic Acid SCHEMBL7996801 | 0.82 | PTGES (0.52) | PTGESBRD4SGMS2L3MBTL1MAPT | |
| SCHEMBL7984591 | 0.80 | PTGES (0.61) | PTGESL3MBTL1MAPTMAOBMEN1 | |
| SCHEMBL7996719 | 0.79 | PTGES (0.64) | PTGESCA1CA2CA9TDP1 | |
| SCHEMBL23876437 | 0.77 | PTGES (1.00) | PTGESCA12CA9MAPK1TDP1 | |
| SCHEMBL16072720 | 0.77 | KCNA3 (0.58) | BRD4TNKS2MAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |