Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 2/20 | 0.60 |
| ▸ | PTGES | O14684 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983849 | 0.81 | PTGES (0.57) | USP8PTGESMAPTMAPK1TP53 | |
| SCHEMBL7996719 | 0.81 | PTGES (0.64) | USP8PTGESMAPTRAB9AMEN1 | |
| SCHEMBL29432454 | 0.76 | RAB9A (0.60) | USP8PTGESMAPTRAB9AMAPK1 | |
| SCHEMBL7984580 | 0.76 | RAB9A (0.60) | USP8PTGESMAPTRAB9AMAPK1 | |
| SCHEMBL1512480 | 0.75 | USP8 (1.00) | USP8MAPTRAB9AMAPK1USP7 | |
| SCHEMBL7984591 | 0.74 | PTGES (0.61) | USP8PTGESMAPTRAB9ATP53 | |
| SCHEMBL7994861 | 0.72 | PTGES (0.59) | PTGESMAPTMEN1HTTKMT2A | |
| SCHEMBL7984790 | 0.72 | PTGES (0.51) | USP8PTGESMAPTMAPK1TP53 | |
| SCHEMBL7994964 | 0.72 | PTGES (0.45) | USP8PTGESMAPTRAB9AMAPK1 | |
| SCHEMBL7984832 | 0.72 | PTGES (0.63) | PTGESMAPTMAPK1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |