Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP8 | P40818 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994861 | 0.88 | PTGES (0.59) | PTGESTDP2TTRKMT2AMAPT | |
| SCHEMBL7994951 | 0.85 | PTGES (0.56) | PTGESTDP2TTRKMT2AMAPT | |
| SCHEMBL7996719 | 0.81 | PTGES (0.64) | PTGESADORA2AADORA1KMT2AUSP8 | |
| SCHEMBL7984832 | 0.80 | PTGES (0.63) | PTGESKMT2AMAPTL3MBTL1TP53 | |
| SCHEMBL7996575 | 0.78 | PTGES (0.55) | PTGESTTRKMT2AMAPTMEN1 | |
| SCHEMBL7994971 | 0.77 | PTGES (0.59) | PTGES | |
| SCHEMBL7996440 | 0.77 | PTGES (0.54) | PTGESKMT2AMAPTALDH1A1POLB | |
| SCHEMBL7984763 | 0.77 | PTGES (0.54) | PTGESKMT2AMAPTALDH1A1POLB | |
| SCHEMBL23876437 | 0.76 | PTGES (1.00) | PTGESADORA3ADORA2AADORA1TTR | |
| SCHEMBL7994940 | 0.75 | PTGES (0.52) | PTGESALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |