Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974490 | 0.90 | NR1H4 (0.47) | ABCC8KCNJ11NR1H4TP53HPGD | |
| SCHEMBL7988522 | 0.89 | NR1H4 (0.44) | ABCC8KCNJ11NR1H4NPC1LMNA | |
| SCHEMBL7987361 | 0.88 | MET (0.45) | ABCC8KCNJ11NR1H4NPC1MAPT | |
| SCHEMBL7985826 | 0.87 | NPC1 (0.41) | NPC1LMNAHPGDHTTRAB9A | |
| SCHEMBL7974237 | 0.87 | KIF11 (0.42) | ABCC8KCNJ11NR1H4KIF11NPC1 | |
| SCHEMBL7984868 | 0.86 | NR1H4 (0.42) | ABCC8KCNJ11NR1H4NPC1MAPT | |
| SCHEMBL7985275 | 0.85 | MET (0.46) | HDAC8HDAC6CNOT7METCYP19A1 | |
| SCHEMBL7974441 | 0.85 | GRK2 (0.43) | HPGDTSHRCNOT7ADORA3 | |
| SCHEMBL7974277 | 0.84 | NR1H4 (0.44) | ABCC8KCNJ11NR1H4HSP90AA1HSP90AB1 | |
| SCHEMBL7991400 | 0.83 | NR1H4 (0.43) | ABCC8KCNJ11NR1H4LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |