Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988522 | 0.88 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11EPHX2HSP90AA1 | |
| SCHEMBL7984471 | 0.88 | NR1H4 (0.41) | NR1H4ABCC8KCNJ11EPHX2ADORA3 | |
| SCHEMBL7987361 | 0.87 | MET (0.45) | NR1H4ABCC8KCNJ11HSP90AA1HSP90AB1 | |
| SCHEMBL7974490 | 0.87 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11ADORA3NR1I2 | |
| SCHEMBL7974458 | 0.87 | ADORA2A (0.44) | ADORA3YTHDC1ADORA2AALDH1A1 | |
| SCHEMBL7984932 | 0.86 | ABCC8 (0.43) | NR1H4ABCC8KCNJ11EPHX2HSP90AA1 | |
| SCHEMBL7974277 | 0.81 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11HSP90AA1HSP90AB1 | |
| SCHEMBL7991400 | 0.80 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11EPHX2HSP90AA1 | |
| SCHEMBL7985010 | 0.80 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11EGLN3 | |
| SCHEMBL7974237 | 0.80 | KIF11 (0.42) | NR1H4ABCC8KCNJ11NPC1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |