Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984281 | 0.91 | MET (0.52) | METHDAC1HDAC6MAPK14 | |
| SCHEMBL7988522 | 0.90 | NR1H4 (0.44) | METNR1H4ABCC8KCNJ11HSP90AA1 | |
| SCHEMBL7974490 | 0.89 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11 | |
| SCHEMBL7984932 | 0.88 | ABCC8 (0.43) | METNR1H4ABCC8KCNJ11HSP90AA1 | |
| SCHEMBL7985165 | 0.88 | MET (0.47) | METHDAC1HDAC6MAPK14MAPT | |
| SCHEMBL7992267 | 0.88 | ICMT (0.44) | METNR1H4ABCC8KCNJ11HDAC1 | |
| SCHEMBL7984868 | 0.87 | NR1H4 (0.42) | METNR1H4ABCC8KCNJ11HSP90AA1 | |
| SCHEMBL7974507 | 0.85 | MET (0.46) | MET | |
| SCHEMBL7986521 | 0.85 | CYP11B1 (0.47) | METMAPTNPC1RAB9A | |
| SCHEMBL7985275 | 0.84 | MET (0.46) | METHDAC6MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |