Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985791 | 0.91 | CYP11B1 (0.40) | CYP11B1CYP11B2CDK9ALDH1A1KDM4C | |
| SCHEMBL7988638 | 0.91 | MET (0.42) | CYP11B1CYP11B2ROCK1ROCK2CDK9 | |
| SCHEMBL7991669 | 0.90 | HDAC1 (0.38) | CYP11B1CYP11B2ROCK1ROCK2CDK9 | |
| SCHEMBL7985334 | 0.89 | ABCG2 (0.46) | CYP11B1CYP11B2CDK9MAOBALDH1A1 | |
| SCHEMBL7974267 | 0.87 | SMN1; SMN2 (0.43) | CYP11B1CYP11B2ROCK2METHPGD | |
| SCHEMBL7991635 | 0.87 | IDO1 (0.37) | CYP11B1CYP11B2ROCK1ROCK2CDK9 | |
| SCHEMBL7988747 | 0.87 | CYP11B1 (0.44) | CYP11B1CYP11B2ROCK1ROCK2MET | |
| SCHEMBL7985275 | 0.86 | MET (0.46) | CYP11B1CYP11B2METGSK3BCYP19A1 | |
| SCHEMBL7974441 | 0.86 | GRK2 (0.43) | CYP11B1CYP11B2ALDH1A1HPGDKDM4C | |
| SCHEMBL7985299 | 0.86 | CDK9 (0.39) | CYP11B1CYP11B2ROCK1ROCK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |