Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 8/20 | 0.42 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | DHPS | P49366 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974043 | 0.94 | GBA1 (0.43) | NPC1RAB9AGBA1PDE5ADHPS | |
| SCHEMBL7974615 | 0.90 | ADORA2A (0.44) | ALDH1A1HTTCNOT7 | |
| SCHEMBL7974286 | 0.89 | DHPS (0.49) | NPC1RAB9AGBA1PDE5ADHPS | |
| SCHEMBL7991678 | 0.87 | HTT (0.40) | RAB9AALDH1A1HTTMAPK1MEN1 | |
| SCHEMBL7984406 | 0.83 | CASR (0.43) | ALDH1A1HTTCNOT7 | |
| SCHEMBL7984242 | 0.82 | CNOT7 (0.45) | ALDH1A1TSHRHTTMAPK1LMNA | |
| SCHEMBL7973871 | 0.82 | ADORA3 (0.40) | ALDH1A1HTTCNOT7 | |
| SCHEMBL7988583 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HTTMAPTMEN1LMNA | |
| SCHEMBL7988551 | 0.81 | ADORA3 (0.43) | ALDH1A1HTTCNOT7 | |
| SCHEMBL7984683 | 0.81 | CNOT7 (0.37) | ALDH1A1HTTCNOT7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |