Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991543 | 0.89 | GAA (0.47) | MAPTGAAHDAC1HDAC6NR1H2 | |
| SCHEMBL7974584 | 0.89 | GAA (0.56) | MAPTGAAHDAC1HDAC6NR1H2 | |
| SCHEMBL7974194 | 0.88 | ABCG2 (0.48) | MAPTGAAHDAC1HDAC6NR1H2 | |
| SCHEMBL7974277 | 0.88 | NR1H4 (0.44) | SERPINE1HDAC1HDAC6NR1H4ABCC8 | |
| SCHEMBL7985850 | 0.88 | GAA (0.49) | GAAHDAC1HDAC6NR1H2NR1H3 | |
| SCHEMBL7991400 | 0.87 | NR1H4 (0.43) | SERPINE1MAPTGAANR1H4ICMT | |
| SCHEMBL7985010 | 0.87 | NR1H4 (0.43) | SERPINE1HDAC1HDAC6NR1H4ABCC8 | |
| SCHEMBL7992267 | 0.86 | ICMT (0.44) | SERPINE1HDAC1HDAC6NR1H4ICMT | |
| SCHEMBL7974490 | 0.86 | NR1H4 (0.47) | NR1H4ABCG2TP53RXFP1ABCC8 | |
| SCHEMBL7991874 | 0.85 | GAA (0.48) | MAPTGAAHDAC1HDAC6NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |