Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974277 | 0.90 | NR1H4 (0.44) | NR1H4HDAC1HDAC6ABCC8KCNJ11 | |
| SCHEMBL7988734 | 0.90 | MET (0.44) | HDAC1HDAC6CYP11B1CYP11B2MET | |
| SCHEMBL7988016 | 0.89 | HDAC1 (0.44) | ICMTNR1H4HDAC1HDAC6ABCC8 | |
| SCHEMBL7985010 | 0.89 | NR1H4 (0.43) | NR1H4HDAC1HDAC6ABCC8KCNJ11 | |
| SCHEMBL7991400 | 0.89 | NR1H4 (0.43) | ICMTNR1H4ABCC8KCNJ11SERPINE1 | |
| SCHEMBL7974469 | 0.89 | HDAC1 (0.40) | HDAC1HDAC6CYP11B1CYP11B2MET | |
| SCHEMBL7987361 | 0.88 | MET (0.45) | NR1H4HDAC1HDAC6ABCC8KCNJ11 | |
| SCHEMBL7987253 | 0.87 | HPGDS (0.40) | ICMTHDAC1HDAC6CYP11B1CYP11B2 | |
| SCHEMBL7974490 | 0.87 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11CYP11B1CYP11B2 | |
| SCHEMBL7985597 | 0.86 | SERPINE1 (0.46) | ICMTNR1H4HDAC1HDAC6ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |