Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974277 | 0.91 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7991400 | 0.90 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11EGLN3SERPINE1 | |
| SCHEMBL7992267 | 0.89 | ICMT (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7991597 | 0.89 | PDE4B (0.39) | HDAC1HDAC6GLAHTTUBE2N | |
| SCHEMBL7974490 | 0.88 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11SMN1; SMN2 | |
| SCHEMBL7988016 | 0.88 | HDAC1 (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7985597 | 0.87 | SERPINE1 (0.46) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7984471 | 0.87 | NR1H4 (0.41) | NR1H4ABCC8KCNJ11EGLN3SERPINE1 | |
| SCHEMBL7973626 | 0.87 | SMN1; SMN2 (0.45) | HDAC1HDAC6GLAHTTUBE2N | |
| SCHEMBL7974012 | 0.87 | ALDH1A1 (0.41) | HDAC1HDAC6GLAHTTUBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |