Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CNOT7 | Q9UIV1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988551 | 0.94 | ADORA3 (0.43) | PDE4BADORA3ADORA2AADORA1CNOT7 | |
| SCHEMBL7992303 | 0.89 | CNOT7 (0.40) | ADORA3ADORA2AADORA1CNOT7TSHR | |
| SCHEMBL7984242 | 0.89 | CNOT7 (0.45) | ADORA3ADORA2AADORA1CNOT7TSHR | |
| SCHEMBL7974012 | 0.88 | ALDH1A1 (0.41) | ADORA3ADORA2AKMT2AKDM4EALDH1A1 | |
| SCHEMBL7974291 | 0.88 | CNOT7 (0.39) | ADORA2AADORA1CNOT7TSHRKDM4E | |
| SCHEMBL7986355 | 0.88 | SIGMAR1 (0.42) | ADORA3ADORA2AADORA1CNOT7TSHR | |
| SCHEMBL7984897 | 0.85 | GAA (0.46) | ADORA2AADORA1TSHRMEN1KMT2A | |
| SCHEMBL7973626 | 0.84 | SMN1; SMN2 (0.45) | ADORA2AADORA1KDM4EMAPK1 | |
| SCHEMBL7988668 | 0.83 | SMN1; SMN2 (0.44) | ADORA3ADORA2ASIGMAR1MAPK1ALDH1A1 | |
| SCHEMBL7984406 | 0.83 | CASR (0.43) | ADORA3ADORA2AADORA1CNOT7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |