Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975252 | 0.90 | HPGD (0.45) | SMN1; SMN2MEN1ALDH1A1KMT2AHIF1A | |
| SCHEMBL7973934 | 0.85 | CYP11B1 (0.45) | SMN1; SMN2ALDH1A1KMT2AHDAC6GAA | |
| SCHEMBL7988129 | 0.85 | MET (0.44) | SMN1; SMN2ALDH1A1KMT2ALMNACYP1A2 | |
| SCHEMBL7987443 | 0.84 | GAA (0.37) | NPC1SMN1; SMN2NPSR1MEN1ALDH1A1 | |
| SCHEMBL7985651 | 0.82 | CYP1A2 (0.41) | SMN1; SMN2ALDH1A1KMT2ACYP1A2GAA | |
| SCHEMBL7992337 | 0.82 | GAA (0.35) | NPC1SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL7985343 | 0.82 | GAA (0.44) | SMN1; SMN2ALDH1A1KMT2AGAATSHR | |
| SCHEMBL7974515 | 0.81 | GAA (0.48) | SMN1; SMN2ALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL7989407 | 0.81 | HPGD (0.44) | SMN1; SMN2MEN1ALDH1A1KMT2AHIF1A | |
| SCHEMBL7987434 | 0.81 | CYP11B1 (0.42) | TP53SMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |