Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991521 | 0.91 | ADORA3 (0.47) | KDM4EMAPTPOLBRXFP1SMN1; SMN2 | |
| SCHEMBL7987851 | 0.87 | LMNA (0.46) | MAPTPOLBFSCN1RXFP1SMN1; SMN2 | |
| SCHEMBL7974040 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1YTHDC1TSHRADRA1D | |
| SCHEMBL7988637 | 0.86 | NPC1 (0.51) | KDM4EMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7991269 | 0.85 | TP53 (0.46) | KDM4EMAPTPOLBRXFP1SMN1; SMN2 | |
| SCHEMBL7984492 | 0.83 | ADORA2A (0.53) | KDM4EALDH1A1YTHDC1AURKAAURKB | |
| SCHEMBL7988763 | 0.82 | NR1H4 (0.43) | KDM4EMAPTSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL7987920 | 0.82 | TP53 (0.47) | KDM4EMAPTRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7985708 | 0.82 | NPC1 (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7974240 | 0.81 | RAB9A (0.47) | KDM4EMAPTPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |